SUSIANTO, INDRA ADI Mesenchymal Stem Cell Secretome-Based Therapeutic Strategies for Ovarian Rejuvenation: A Focus on FSH and Estradiol Levels. In: International Conference of biotechnology and biomedic science, 1-2 agustus 2026, Semarang. (In Press)
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Abstract
Background: Ovarian rejuvenation for Premature ovarian insufficiency (POI) offers a regenerative approach to restore ovarian function and microenvironment. MSC-derived secretome, rich in cytokines, growth factors, and vesicles, may promote follicle survival, angiogenesis, tissue repair, and endocrine recovery. This study assesses MSC secretome therapy as an ovarian rejuvenation strategy for women with POI, focusing on changes in FSH and estradiol levels. Methods: A prospective observational study was conducted in 30 women with POI and infertility. Baseline demographic and reproductive characteristics were recorded. Serum FSH and estradiol levels were measured before treatment and at three months after intraovarian administration of the MSC secretome. Follicular development was assessed with transvaginal ultrasonography.Results: Participants had a mean age of 41.5 years and exhibited severely diminished ovarian reserve. Before treatment, mean serum FSH and estradiol levels were 36.17 mIU/mL and 15.17 pg/mL, respectively. Three months following MSC secretome therapy, mean FSH levels decreased markedly to 9.87 mIU/mL, while mean estradiol levels increased to 166.67 pg/mL. Ultrasonographic evaluation demonstrated improved follicular development, indicating enhanced ovarian responsiveness after treatment. Conclusions: MSC secretome therapy shows potential for ovarian rejuvenation, normalizing FSH, restoring estradiol, and improving follicular growth. It may recover ovarian endocrine function via regenerative and paracrine mechanisms, providing a cell-free strategy for POI-related fertility.
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Subjects: | 600 Technology (Applied sciences) 600 Technology (Applied sciences) > 610 Medicine and health |
| Divisions: | Faculty of Medicine |
| Depositing User: | Mr Indra Adi Susianto |
| Date Deposited: | 01 Sep 2026 03:18 |
| Last Modified: | 03 Sep 2026 12:20 |
| URI: | http://repository.unika.ac.id/id/eprint/40166 |
| Keywords: | UNSPECIFIED |
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