Alpinia galanga Extract Inhibits MCF-7/HER2+ Cells by Inducing Apoptosis

IBRAHIM, SUGENG Alpinia galanga Extract Inhibits MCF-7/HER2+ Cells by Inducing Apoptosis. Journal of Science and Technology Research for Pharmacy.

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Abstract

Background: Cancer is a disease caused by abnormal growth of body tissue cells. Cancer treatment strategy by induce apoptosis and inhibit proliferation. Aim: This research aims to examine the anticancer effect of Alpinia galanga extract on MCF-7/HER2+ breast cancer cells. Method: The MTT Assay cytotoxic test was carried out to determine the growth inhibitory activity. Apoptotic assay to determine the activity of compounds in apoptosis, as well as through a structural approach utilizing various virtual platforms to monitor its activity. Result: Based on the MTT assay Alpinia galanga extract possessed cytotoxic effect in dose-dependent manner with IC50 value of 330.79 μg/mL. The extract induces apoptosis of MCF-7 cells up to 25.56%. Conclusion: It can be concluded that Alpinia galanga extract demonstrated cytotoxic activity toward MCF7/HER2+ breast through apoptosis induction. This extract had an opportunity to be developed as a potential anticancer agent to overcome breast cancer diseases.

Item Type: Article
Subjects: 600 Technology (Applied sciences) > 610 Medicine and health
Depositing User: Mrs Rikarda Ratih
Date Deposited: 09 Mar 2022 03:32
Last Modified: 09 Mar 2022 03:32
URI: http://repository.unika.ac.id/id/eprint/28112

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